Place Jello powder in a medium bowl. Carefully pour boiling water over the powder, stir until dissolved. Let sit at room temperature until completely cooled.
While the Jello is cooling, make the crust. Stir together crushed pretzels with sugar and melted butter. Press into the bottom of a 9x13-inch pan. Chill for at least 30 minutes.
Beat cream cheese and sugar in a large bowl with an electric mixer until smooth. Mix in Cool Whip.
Spread cream cheese mixture on top of the crust. Ensure it touches all edges. Chill for 1 hour.
Arrange strawberries in a single layer over the cream cheese layer. Carefully pour cooled Jell-o evenly over strawberries and cheesecake. Chill until set, about 3 hours.
The dessert can be prepared up to 24 hours ahead. Serve within 3 days.
Notes
A crowd-pleasing summer dessert with fresh strawberries and a crunchy pretzel crust.